- TWS119
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- $43.00 / 5mg
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2026-05-11
- CAS:601514-19-6
- Min. Order:
- Purity: 99.63%
- Supply Ability: 10g
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| | GSK-3BETA INHIBITOR XII Basic information |
| Product Name: | GSK-3BETA INHIBITOR XII | | Synonyms: | TWS119;GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;CS-1924;TWS-119; TWS 119;CS-445;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate | | CAS: | 601514-19-6 | | MF: | C18H14N4O2 | | MW: | 318.33 | | EINECS: | | | Product Categories: | Akt;mTOR;PI3K;Inhibitors | | Mol File: | 601514-19-6.mol |  |
| | GSK-3BETA INHIBITOR XII Chemical Properties |
| Melting point | 249 °C | | density | 1.42 | | storage temp. | 2-8°C | | solubility | insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO | | pka | 8.99±0.10(Predicted) | | form | powder | | color | white to beige | | InChI | 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22) | | InChIKey | VPVLEBIVXZSOMQ-UHFFFAOYSA-N | | SMILES | OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | GSK-3BETA INHIBITOR XII Usage And Synthesis |
| Uses | Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition. | | Uses | TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor. | | Definition | ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles. | | General Description | A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM). | | Biological Activity | Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs). | | Biochem/physiol Actions | TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production. | | target | GSK-3β | | storage | Store at +4°C | | references | [1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260. |
| | GSK-3BETA INHIBITOR XII Preparation Products And Raw materials |
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