| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:DB1976
CAS:1557397-51-9
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，more
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:DB1976
CAS:1557397-51-9
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:DB1976
CAS:1557397-51-9
Purity:98.94% Package:1mg/RMB 1150;5mg/RMB 2390;10mg/RMB 3400
|
DB1976 manufacturers
- DB1976
-
- $118.00 / 1mg
-
2024-11-12
- CAS:1557397-51-9
- Min. Order:
- Purity: 98.94%
- Supply Ability: 10g
- DB1976
-
- $118.00 / 1mg
-
2024-11-12
- CAS:1557397-51-9
- Min. Order:
- Purity: 98.94%
- Supply Ability: 10g
|
| Product Name: | DB1976 | | Synonyms: | DB1976;DB1976,DB-1976;1H-Benzimidazole-6-carboximidamide, 2,2'-(2,5-selenophenediyl)bis- | | CAS: | 1557397-51-9 | | MF: | C20H16N8Se | | MW: | 447.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1557397-51-9.mol |  |
| | DB1976 Chemical Properties |
| Boiling point | 796.5±70.0 °C(Predicted) | | pka | 9.42±0.10(Predicted) |
| | DB1976 Usage And Synthesis |
| Description | DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding and strongly inhibits the PU.1/DNA complex in vitro. DB1976 has apoptosis-inducing effect. | | Uses | DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 has apoptosis-inducing effect[1][2][3]. | | References | [1] Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42(2):1379-90. DOI:10.1093/nar/gkt955
[2] Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44(9):4005-13. DOI:10.1093/nar/gkw229
[3] Antony-Debré I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313. DOI:10.1172/JCI92504 |
| | DB1976 Preparation Products And Raw materials |
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