Mal-amido-PEG12-NHS ester manufacturers
- Mal-amido-PEG12-NHS
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2025-06-07
- CAS:2101722-60-3
- Min. Order: 250mg
- Purity: >95.00%
- Supply Ability: 250mg
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| | Mal-amido-PEG12-NHS ester Basic information |
| Product Name: | Mal-amido-PEG12-NHS ester | | Synonyms: | 4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxa-40-azatritetracontanoic acid, 43-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-41-oxo-, 2,5-dioxo-1-pyrrolidinyl ester;Mal-dPEG12-NHS Ester;Maleimide-PEG12-NHS | | CAS: | 2101722-60-3 | | MF: | C38H63N3O19 | | MW: | 865.92 | | EINECS: | | | Product Categories: | | | Mol File: | 2101722-60-3.mol |  |
| | Mal-amido-PEG12-NHS ester Chemical Properties |
| density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | -20°C, stored under nitrogen, away from moisture | | form | Solid-Liquid Mixture | | pka | 15.01±0.46(Predicted) | | color | White to off-white |
| | Mal-amido-PEG12-NHS ester Usage And Synthesis |
| Description | Mal-amido-PEG12-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Uses | Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-amido-PEG12-NHS ester Preparation Products And Raw materials |
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