2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)-

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2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- manufacturers

  • LS-104
  • LS-104 pictures
  • $1520.00
  • 2026-07-27
  • CAS:368836-72-0
  • Purity:
  • Supply Ability: 10g
2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- Basic information
Product Name:2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)-
Synonyms:2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)-;LS-104
CAS:368836-72-0
MF:C19 H16 N2 O3
MW:320.34
EINECS:
Product Categories:
Mol File:368836-72-0.mol
2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- Structure
2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- Chemical Properties
Boiling point 651.4±55.0 °C(Predicted)
density 1.298±0.06 g/cm3(Predicted)
pka9.24±0.10(Predicted)
Safety Information
MSDS Information
2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- Usage And Synthesis
UsesLS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2, Bcr-Abl and FLT3. LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies[1][2].
References[1] Lipka DB, et al. LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells. Mol Cancer Ther. 2008 May;7(5):1176-84. DOI:10.1158/1535-7163.MCT-07-2215
[2] Kasper S, et al. The kinase inhibitor LS104 induces apoptosis, enhances cytotoxic effects of chemotherapeutic drugs and is targeting the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Leuk Res. 2008 Nov;32(11):1698-708. DOI:10.1016/j.leukres.2008.05.003
2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)- Preparation Products And Raw materials
Tag:2,4-Pentadienamide, 2-cyano-5-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E,4E)-(368836-72-0) Related Product Information
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