24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-

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24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Basic information
Product Name:24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-
Synonyms:24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-;DHCE. (-)-Triptohypol C;Dihydrocelastrol;Triptohypol C
CAS:193957-88-9
MF:C29H40O4
MW:452.64
EINECS:
Product Categories:
Mol File:193957-88-9.mol
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Structure
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Chemical Properties
Boiling point 596.0±50.0 °C(Predicted)
density 1.21±0.1 g/cm3(Predicted)
pka4.79±0.70(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Usage And Synthesis
UsesTriptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
DefinitionChEBI: Triptohypol C is a pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii. It has a role as a plant metabolite and an apoptosis inducer. It is a pentacyclic triterpenoid, a monocarboxylic acid and a member of benzenediols.
in vivo

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

Animal Model:Zebrafish[1]
Dosage:0.5μM, 1μM and 1.25μM
Administration:72 h
Result:Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25μM for 24h or at a concentration of 0.5μM for 72h.
IC 50Nur77/NR4A1
References[1] Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187. DOI:10.1016/j.ejmech.2019.05.009
24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)- Preparation Products And Raw materials
Tag:24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-, (9β,13α,14β,20α)-(193957-88-9) Related Product Information
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