| Company Name: |
Changzhou Hopschain Chemical Co.,Ltd.
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| Tel: |
0519-85528066 13775048983 |
| Email: |
sales@hopschem.com |
| Products Intro: |
Product Name:SH-5
CAS:701976-54-7
Purity:98% Package:1mg;10mg;100mg;1g
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| Product Name: | SH-5 | | Synonyms: | SH-5;AKT INHIBITOR II;D-3-DEOXY-2-O-METHYL-MYO-INOSITOL 1-[(R)-2-METHOXY-3-(OCTADECYLOXY)PROPYL HYDROGEN PHOSPHATE];PIA 5;1-Deoxy-6-O-methyl-L-chiro-inositol 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];L-chiro-Inositol, 1-deoxy-6-O-methyl-, 5-[(2R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate];SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II;SH-5, Akt inhibitor | | CAS: | 701976-54-7 | | MF: | C29H59O10P | | MW: | 598.75 | | EINECS: | | | Product Categories: | SiChem | | Mol File: | 701976-54-7.mol |  |
| storage temp. | -20°C | | solubility | DMSO: 10mg/mL | | form | solid | | color | white |
| Uses | SH-5 is a potent AKT inhibitor. SH-5 potentiates the apoptosis induced by tumor necrosis factor. SH-5 blocks NF-kB activation induced by TNF-a, lipopolysaccharide (HY-D1056), phorbol ester (HY-18739), and cigarette smoke[1]. | | Biological Activity | Cell permeable: yes', 'Primary Target
Akt', 'Product does not compete with ATP.', 'Reversible: yes | | Enzyme inhibitor | This phosphatidylinositol analogue (FWfree-acid = 598.76 g/mol), also known as SH-5, inhibits the proto-oncogenic serine/threonine kinase Akt (protein kinase B), inducing apoptosis. Specific inhibition of Akt by these compounds validates ligand design targeted to the PH domains of crucial signaling proteins, thus providing a unique class of possible cancer therapeutics. | | References | [1] Sethi G, et al. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. DOI:10.1016/j.bcp.2008.05.023 |
| | SH-5 Preparation Products And Raw materials |
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