Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-

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Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn

Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- manufacturers

  • CAY17c
  • CAY17c pictures
  • $1560.00
  • 2026-04-22
  • CAS:2414373-11-6
  • Purity:
  • Supply Ability: 10g
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Basic information
Product Name:Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-
Synonyms:Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-;CAY17c;CAY17c,CAY-17c
CAS:2414373-11-6
MF:C24H30N4O4S
MW:470.58
EINECS:
Product Categories:
Mol File:2414373-11-6.mol
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Structure
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Chemical Properties
density 1.38±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMF: slightly soluble,DMSO: slightly soluble
form A crystalline solid
pka9.46±0.20(Predicted)
Safety Information
MSDS Information
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Usage And Synthesis
Biological ActivityCAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50 = 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1 It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620, and DLD-1 colorectal cancer cells (IC50s = 0.45, 1.78, and 2.11 μM, respectively), as well as induces apoptosis and autophagy in HCT116 cells. It reduces tumor growth in an HCT116 mouse xenograft model when administered at doses of 15 and 30 mg/kg.
References1.Pan, Z., Li, X., Wang, Y., et al.Discovery of thieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as bromodomain-containing protein 4/histone deacetylase dual inhibitors induce autophagic cell death in colorectal carcinoma cellsJ. Med. Chem.63(7)3678-3700(2020)
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Preparation Products And Raw materials
Tag:Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-(2414373-11-6) Related Product Information
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