2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- manufacturers
- Melanin probe-1
-
- $122.00
-
2026-05-11
- CAS:1420844-62-7
- Purity:
- Supply Ability: 10g
|
| | 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- Basic information |
| | 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- Chemical Properties |
| Boiling point | 370.3±37.0 °C(Predicted) | | density | 1.102±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 250 mg/mL (1044.76 mM) | | form | Oil | | pka | 13.30±0.46(Predicted) | | color | Light yellow to yellow |
| | 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- Usage And Synthesis |
| Uses | Melanin probe-1 is an 18F-picolinamides based PET probe. Melanin probe-1 can be used for PET imaging of malignant melanoma. Melanin probe-1 exhibits high tumor targeting efficiency, excellent tumor imaging contrasts, desirable biodistribution patterns, and good in vivo stability[1]. | | in vivo | Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency[1].
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection[1]. | Animal Model: | C57BL/6 mice bearing B16F10 murine melanomas[1] | | Dosage: | 3.7 MBq (100 μCi) | | Administration: | Tail vein | | Result: | The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively. |
| | References | [1] Liu H, et al. Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma. J Med Chem. 2013;56(3):895‐901. DOI:10.1021/jm301740k |
| | 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- Preparation Products And Raw materials |
|