2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl-

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2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl- manufacturers
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl- Basic information
Product Name:2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl-
Synonyms:2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl-;CaV1.3 antagonist-1;cp-PYT;1-(3-Chlorophenethyl)-3-cyclopentylpyrimidine-2,4,6-(1H,3H,5H)-trione
CAS:1391385-57-1
MF:C17H19ClN2O3
MW:334.8
EINECS:
Product Categories:
Mol File:1391385-57-1.mol
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl- Structure
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl- Chemical Properties
Boiling point 469.3±47.0 °C(Predicted)
density 1.335±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 100 mg/mL (298.69 mM; Need ultrasonic)
pka6.10±0.40(Predicted)
form Solid
color White to light yellow
Safety Information
MSDS Information
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl- Usage And Synthesis
UsesCaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].
IC 50CaV1.3: 1.7 μM (IC50)
References[1] Soosung Kang, et al. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat Commun. 2012;3:1146. DOI:10.1038/ncomms2149
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl- Preparation Products And Raw materials
Tag:2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-[2-(3-chlorophenyl)ethyl]-3-cyclopentyl-(1391385-57-1) Related Product Information
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