Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]-

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Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- Basic information
Product Name:Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]-
Synonyms:Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]-;1Z105
CAS:1438280-73-9
MF:C25H26N4O2S
MW:446.56
EINECS:
Product Categories:
Mol File:1438280-73-9.mol
Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- Structure
Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- Chemical Properties
density 1.34±0.1 g/cm3(Predicted)
pka14.14±0.20(Predicted)
Safety Information
MSDS Information
Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- Usage And Synthesis
Uses1Z105 is an oral active TLR4/MD2 ligand. 1Z105 enhances dendritic cell maturation and antigen presentation and prevents rthritis[1][2].
References[1] Goff PH, et al. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015;89(6):3221-3235. DOI:10.1128/JVI.03337-14
[2] Hayashi T, et al. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014;350(2):330-340. DOI:10.1124/jpet.114.214312
Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]- Preparation Products And Raw materials
Tag:Acetamide, N-cyclohexyl-2-[(4,5-dihydro-5-methyl-4-oxo-3-phenyl-3H-pyrimido[5,4-b]indol-2-yl)thio]-(1438280-73-9) Related Product Information
Lipopolysaccharides, from E. coli O55:B5 TLR4 Protein, Human (sf9, His, Solution) TLR2 protein, mouse (SF9, his) TLR3 Protein, CYNOMOLGUS (681A.A, HEK293, HIS) TLR3 Protein, Human (HEK293, Fc) TLR2 protein, RAT (SF9, HIS)