1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-

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1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- manufacturers

  • ASK1-IN-2
  • ASK1-IN-2 pictures
  • $68.00
  • 2026-07-27
  • CAS:2541792-70-3
  • Purity: 99.36%
  • Supply Ability: 10g
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Basic information
Product Name:1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-
Synonyms:1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-;6-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-1H-indole-2-carboxamide;ASK1-IN-2;colitis,ulcerative,signal-regulating,ASK1 IN 2,ASK1IN2,inhibit,MAP kinase kinase kinase, MEKK, MAPKKK,Apoptosis,ASK1,Inhibitor,ASK-1-IN-2,MAP3K;ASK1-IN-2, 10 mM in DMSO
CAS:2541792-70-3
MF:C19H17FN6O
MW:364.38
EINECS:
Product Categories:
Mol File:2541792-70-3.mol
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Structure
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Chemical Properties
density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (686.10 mM; Need ultrasonic)
pka12.33±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Usage And Synthesis
UsesASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].
in vivo

ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) improves dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice[1].
ASK1-IN-2 (25 mg/kg; p.o. daily for 7 d) blocks ASK1-p38/JNK signaling pathways and reduces inflammatory cytokine levels in DSS-induced mouse colon tissues[1].
ASK1-IN-2 (1 mg/kg; i.v.) shows low clearance (CL=1.38 L/h/kg) and moderate half-life (T1/2=1.45 h) in rats[1].
ASK1-IN-2 (10 mg/kg; p.o.) shows high oral exposure (AUClast=4517 hng/mL), 62.2% oral bioavailability and acceptable terminal half-life (T1/2=2.31 h) in rats[1].

Animal Model:Male ICR mice (18-22 g, 6-8 weeks) were given 3% DSS (w/v) orally in drinking water[1]
Dosage:25 mg/kg
Administration:P.o. daily for 7 days
Result:Induced a significant recovery of body weight loss, with an increase of +11.2%.
Decreased the disease activity index (DAI) score about a 2 unit.
Significantly prevented colon shortening.
Attenuated a severe colonic tissue damage and infiltration of inflammatory cells.
Animal Model:Male SD rats [1]
Dosage:1 mg/kg for i.v.; 10 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration:I.v. and p.o. administration
Result:I.v.: CL=1.38 L/h/kg; T1/2=1.45 h.
P.o.: AUClast=4517 hng/mL; F=62.2%; T1/2=2.31 h.
IC 50ASK1: 32.8 nM (IC50)
References[1] Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114. DOI:10.1016/j.ejmech.2020.113114
1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]- Preparation Products And Raw materials
Tag:1H-Indole-2-carboxamide, 6-fluoro-N-[6-[4-(1-methylethyl)-4H-1,2,4-triazol-3-yl]-2-pyridinyl]-(2541792-70-3) Related Product Information
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