3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE

Request For Quotation
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:MTEP
CAS:329205-68-7
Package:25mg;1520USD|100mg;2500USD|50mg;1980USD
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:MTEP
CAS:329205-68-7
Purity:>=99% Package:$109.9/5mg;$460.9/25mg;Bulk package Remarks:99%
Company Name: Shanghai BornBio Co,.LTD
Tel: +86-18916339313 +86-18916339313
Email: info@born-bio.com
Products Intro: Product Name:3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
CAS:329205-68-7
Purity:0.99 Package:1KG;100KG
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532; 18210857532
Email: jkinfo@jkchemical.com
Products Intro: Product Name:MTEP Hydrochloride
CAS:329205-68-7
Package:100Mg,10Mg,25Mg
Company Name: Shanghai Tauto Biotech Co., Ltd.  
Tel: 021-51320588
Email: tauto@tautobiotech.com
Products Intro: Product Name:MTEP
CAS:329205-68-7
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:AG-CR1-0022-M025

3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE manufacturers

  • MTEP
  • MTEP pictures
  • $1630.00
  • 2026-05-21
  • CAS:329205-68-7
  • Purity:
  • Supply Ability: 10g
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Basic information
Product Name:3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE
Synonyms:3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE;MTEP;3-(2-Methyl-thiazol-4-ylethynyl)-pyridine;2-methyl-4-(pyridin-3-ylethynyl)thiazole;3-[2-(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine;2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole;Pyridine, 3-[(2-methyl-4-thiazolyl)ethynyl]-;MTEP hydrochloride >=98% (HPLC)
CAS:329205-68-7
MF:C11H8N2S
MW:200.26
EINECS:
Product Categories:
Mol File:Mol File
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Structure
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Chemical Properties
Boiling point 360.7±17.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility methanol: 1mg/mL
DMSO: 5mg/mL
pka3.41±0.12(Predicted)
form White to yellow solid.
color white to yellow
InChI1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3
InChIKeyNRBNGHCYDWUVLC-UHFFFAOYSA-N
SMILES[s]1c(nc(c1)C#Cc2cnccc2)C
Safety Information
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Usage And Synthesis
UsesMTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.
Biological ActivityCell permeable: yes', 'Primary Target
mGluR5', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 5 nM in Ca2+-flux assay', 'Target Ki: 16 nM for mGluR5 (metabotropic glutamate receptor subtype-5)
in vivo

MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)[2].
MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice[3].

Animal Model:Male Wistar rats (215-315 g, 5-9/group)[2]
Dosage:1, 3 and 5 mg/kg
Administration:IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)
Result:Inhibited the catalepsy induced by Haloperidol (HY-14538).
Animal Model:Male C57BL/6J mice (23-25 g)[3]
Dosage:0.3, 1 and 3 mg/kg
Administration:IP, 1 h before the test
Result:Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.
IC 50mGluR5: 5 nM (IC50); mGluR5: 16 nM (Ki)
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Preparation Products And Raw materials
Tag:3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE(329205-68-7) Related Product Information
MPEP FENOBAM