| Company Name: |
ChemeGen |
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18818260767 |
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Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- manufacturers
- CAY10773
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- $1690.00
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2026-05-11
- CAS:1648546-79-5
- Purity:
- Supply Ability: 10g
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| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Basic information |
| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Chemical Properties |
| Boiling point | 547.5±50.0 °C(Predicted) | | density | 1.488±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml | | form | A crystalline solid | | pka | 12.87±0.70(Predicted) |
| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Usage And Synthesis |
| Uses | Anticancer agent 251 (compound 7j) can induce cell death of bladder cancer cell T24 by inducing apoptosis, autophagy or ferroptosis[1]. | | Biological Activity | CAY10773 is a derivative of the ferroptosis inducer sorafenib .1 It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours. | | References | 1.Chen, J.-N., Li, T., Cheng, L., et al.Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivativesEur. J. Med. Chem.205112661(2020) |
| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Preparation Products And Raw materials |
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