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| | o-Toluenesulfonamide Basic information |
| | o-Toluenesulfonamide Chemical Properties |
| Melting point | 156-158 °C (lit.) | | Boiling point | 221 °C | | density | 1.2495 (rough estimate) | | vapor pressure | 0-0.008Pa at 25℃ | | refractive index | 1.6100 (estimate) | | Fp | 178°C | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Very Slightly, Heated) | | pka | 10.17±0.60(Predicted) | | form | powder | | color | White to Off-White | | Water Solubility | Soluble in water (1.6 g/L at 25°C). | | BRN | 1102362 | | Henry's Law Constant | 2.1×101 mol/(m3Pa) at 25℃, HSDB (2015) | | Cosmetics Ingredients Functions | PLASTICISER | | InChI | 1S/C7H9NO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3,(H2,8,9,10) | | InChIKey | YCMLQMDWSXFTIF-UHFFFAOYSA-N | | SMILES | Cc1ccccc1S(N)(=O)=O | | LogP | 0.6-0.9 at 20-25℃ | | CAS DataBase Reference | 88-19-7(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenesulfonamide, 2-methyl-(88-19-7) | | EPA Substance Registry System | Benzenesulfonamide, 2-methyl- (88-19-7) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36-40 | | Safety Statements | 26-36/37 | | WGK Germany | 1 | | RTECS | XT5075000 | | TSCA | TSCA listed | | HS Code | 29350090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Carc. 2
Eye Irrit. 2 | | Hazardous Substances Data | 88-19-7(Hazardous Substances Data) |
| | o-Toluenesulfonamide Usage And Synthesis |
| Chemical Properties |
o-Toluenesulfonamide is white powder or crystal which is soluble in water (1.6 g/L at 25 °C ). Soluble in alcohol; slightly soluble in water and ether. Combustible.
| | Uses | 2-Methylbenzene-1-sulfonamide is a methylated sulfonamide and a major Impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity. | | Uses | Plasticizer of thermosetting resin, as a raw material used in organic synthesis, preparation of nail polish, dyes, fluorescent pigments and coatings. | | Uses | o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity. | | General Description | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. o-Toluenesulfonamide is a major impurity in artificial sweetening substances containing saccharin. | | Toxicity evaluation | Acute toxicity of o-toluenesulfonamide in rats: The oral LD50 value in rats was greater than 2,000 mg/kg b.w. for males and between 1,000 and
2,000 mg/kg b.w. for females. In an oral repeated dose study in rats, the major effects of this chemical were clinical signs such as
decreased locomotor activity and prone position, and histopathological change in liver. The
NOAEL is considered to be 20 mg/kg b.w./day for both sexes. | | Safety Profile | Suspected carcinogen
with experimental tumorigenic data. Mildly
toxic by ingestion. Experimental
reproductive effects. Mutation data
reported. An eye irritant. When heated to
decomposition it emits very toxic fumes of
NOx and SOx. Used as a chemical
intermediate in the production of saccharin. | | Purification Methods | Crystallise the amide from hot H2O (m 153o), then from EtOH or Et2O/pet ether. The N-o-toluenesulfonylphthalimide has m 182o (from EtOH). [Evans & Dehn J Am Chem Soc 51 3652 1929, Beilstein 11 H 86, 11 I 23, 11 II 39, 11 III 167, 11 IV 229.] |
| | o-Toluenesulfonamide Preparation Products And Raw materials |
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