- Alagebrium chloride
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- $10.00
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2021-10-21
- CAS:341028-37-3
- Min. Order: 1Kg/Bag
- Purity: 99%
- Supply Ability: 20 Tons
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| | Alagebrium chloride Basic information |
| Product Name: | Alagebrium chloride | | Synonyms: | 2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride;ALT-711;Dimethyl-3-(2-oxo-2-phenyl)-chloride;(Alagebrium) (thiazolium salt);4,5-Dimethyl-3-(2-oxo-2-phenyl)-thiazoliumchloride;2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenylethanone chloride;2-(4,5-dimethyl-1,3-thiazol-3-ium-3-yl)-1-phenyl-ethanone chloride;2-(4,5-dimethylthiazol-3-ium-3-yl)-1-phenyl-ethanone chloride | | CAS: | 341028-37-3 | | MF: | C13H14ClNOS | | MW: | 267.77 | | EINECS: | 636-473-0 | | Product Categories: | | | Mol File: | 341028-37-3.mol |  |
| | Alagebrium chloride Chemical Properties |
| Melting point | 212 °C(dec.) | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | Merck | 14,203 | | InChI | InChI=1S/C13H14NOS.ClH/c1-10-11(2)16-9-14(10)8-13(15)12-6-4-3-5-7-12;/h3-7,9H,8H2,1-2H3;1H/q+1;/p-1 | | InChIKey | MKOMESMZHZNBIZ-UHFFFAOYSA-M | | SMILES | C([N+]1=CSC(C)=C1C)C(C1C=CC=CC=1)=O.[Cl-] | | CAS DataBase Reference | 341028-37-3(CAS DataBase Reference) |
| | Alagebrium chloride Usage And Synthesis |
| Uses | Prevention and treatment of cardiovascular complications
of aging, diabetes, and end stage renal disease;
diabetic multisymptom pathology (other than cardiovascular)
including retinopathy, neuphropathy, neuropathy, and
ulcers (advanced glycosylation endpr. | | Uses | Alagebrium Chloride is used in the treatment of obesity resulting from a diet high in both fat and AGE that causes renal impairment in animals. Alagebrium inhibits AGE-mediated formation of reactive oxygen species (ROS), extracellular signal-regulated kinase phosphorylation, and cyclooxygenase-2 expression. | | in vivo | Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice[1]. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium[2]. |
| | Alagebrium chloride Preparation Products And Raw materials |
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