1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-

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1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Basic information
Product Name:1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-
Synonyms:1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-;TDRL 551;TDRL551;TDRL-551;TDRL 551,TDRL551;TDRL-551, 10 mM in DMSO;5-(5-(2-Chloro-7-ethoxyquinolin-3-yl)-3-(4-iodophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-5-oxopentanoic acid
CAS:1644626-43-6
MF:C25H23ClIN3O4
MW:591.83
EINECS:
Product Categories:
Mol File:1644626-43-6.mol
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Structure
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Chemical Properties
Boiling point 704.0±70.0 °C(Predicted)
density 1.62±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic)
pka4.65±0.10(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Usage And Synthesis
UsesTDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].
Biological ActivityTDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].
References[1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33.
1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Preparation Products And Raw materials
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