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| | (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Basic information |
| Product Name: | (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride | | Synonyms: | (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride;Org-6906 free | | CAS: | 67384-25-2 | | MF: | C13H16ClN | | MW: | 221.73 | | EINECS: | 266-675-0 | | Product Categories: | | | Mol File: | 67384-25-2.mol |  |
| | (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Chemical Properties |
| | (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Usage And Synthesis |
| Description | Org-6906 is a dual of monoamine uptake inhibitor and α2 adrenoceptor antagonist potentially for the treatment. Org-6906 facilitated potassium-stimulated release of noradrenaline from slices of cortex, displaced [3H]rauwolscine and [3H]dihydroergocryptine from their binding sites but only weakly blocked alpha 1-adrenoceptors. The alpha 2-adrenolytic properties were also apparent in behavioural interaction models. The compound antagonized the sleep-inducing effects of clonidine in chicks and mice and it antagonized the mydriasis induced by clonidine in the rat. | | Uses | Org 6906 is a monoamine reuptake inhibitor that promotes monoaminergic neurotransmission by inhibiting the reuptake of noradrenaline, dopamine, and serotonin. Org 6906 is also an α2 Adrenergic Receptor antagonist, with a pKi value of 6.3 (using the selective α2 adrenergic receptor ligand [3H]rauwolscine as a ligand). Org 6906 exhibits antidepressant activity and can be used in research related to neurological disorders[1]. | | IC 50 | α2-adrenergic receptor: 6.5 (pKi) | | References | [1] de Boer T, et al. The pharmacological profile of Org 6906, a potential non-sedative antidepressant that combines monoamine uptake inhibition with alpha 2-adrenolytic activity. Neuropharmacology. 1988 Mar;27(3):251-60. DOI:10.1016/0028-3908(88)90041-x |
| | (5alpha,8alpha,9alpha)-5,8,9,10-tetrahydro-5,9-methanobenzocycloocten-8-ylammonium chloride Preparation Products And Raw materials |
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