tigloidine manufacturers
- Tigloidin
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- $1360.00 / 100mg
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2026-03-12
- CAS:495-83-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | tigloidine Basic information |
| Product Name: | tigloidine | | Synonyms: | tigloidine;2-Methylcrotonic acid (1R,5S)-tropan-3β-yl ester;3α-Tigloyloxytropane;Tigloyltropine;Tiglyssin;Tigloyltropeine;Tigloidin;Tigloyl pseudotropine | | CAS: | 495-83-0 | | MF: | C13H21NO2 | | MW: | 223.314 | | EINECS: | 2078105 | | Product Categories: | | | Mol File: | 495-83-0.mol |  |
| | tigloidine Chemical Properties |
| Boiling point | 290.2±33.0 °C(Predicted) | | density | 1.06±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | Oil | | pka | 10.03±0.40(Predicted) | | color | Light yellow to yellow |
| | tigloidine Usage And Synthesis |
| Description | A tropine alkaloid isolated from Duboisia rnyoporoides, this base is a colourless
syrup which yields crystalline salts. The hydrobromide forms colourless, tabular
crystals m.p. 234-5°C and is optically inactive; the aurichloride crystallizes as
yellow plates, m.p. 213.5- 2140 C; the picrate as yellow rectangular plates, m.p.
239°C and the methiodide as square plates, m.p. 244-5°C. The alkaloid is
unsaturated and the hydro bromide, on hydrogenation, furnishes dihydrotigloidine,
giving a picrate, m.p. l34-5°C. When treated with bromine in CHC13 it forms
dibromodihydrotigloidine, m.p. 187°C (dec.). The free base may be hydrolyzed
by boiling with H20 when it furnishes pseudotropine and tiglic acid. The base is
therefore the tiglyl ester of pseudotropine. By comparison, tiglyltropine gives a
hydrobromide with m.p. 207°C and a picrate, m.p. 200°C. | | Uses | Tigloidin is an analogue of atropine, with anticholinergic activity. | | in vivo | Tigloidine hydrobromide (20-60 mg/kg, i.p.) fails to protect the mice against the lethal effect of physostigmine, but at 100 mg/kg and above, it protects 80% of the animals against the lethal effect. Tigloidine markedly prevents tremor and salivation produced by tremorine at 80-100 mg/kg, but fails to prevent these effects in doses up to 40 mg/kg. Tigloidine (up to 100 mg/kg, i.p) does not significantly affects reserpine and tetrabenazine induced sedation and ptosis in mice. Tigloidine (25-50 mg/kg, i.p.) also fails to cause any behavioral changes in the cats[1]. | | References | Barger, Martin, Mitchel1.,J. Chern. Soc., 1820 (1937) |
| | tigloidine Preparation Products And Raw materials |
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