CP-547632 TFA

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:CP-547632 TFA
CAS:2805804-54-8
Package:100mg;3400USD|25mg;1970USD|50mg;2580USD
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:CP-547632 TFA
CAS:2805804-54-8
Package:1ml Remarks:T94692
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 15801484223;
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Products Intro: Product Name:CP-547632 TFA
Purity:98% Package:5mg;10mg;25mg;50mg;100mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:CP-547632 TFA
CAS:2805804-54-8
Package:100mg/RMB 23500;25mg/RMB 13900;50mg/RMB 18300
Company Name: MedChemExpress  
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Products Intro: Product Name:CP-547632 TFA

CP-547632 TFA manufacturers

  • CP-547632 TFA
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  • $3400.00 / 100mg
  • 2026-04-20
  • CAS:2805804-54-8
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  • Supply Ability: 10g
CP-547632 TFA Basic information
Product Name:CP-547632 TFA
Synonyms:CP-547632 TFA;4-Isothiazolecarboxamide, 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-, 2,2,2-trifluoroacetate (1:1)
CAS:2805804-54-8
MF:C20H24BrF2N5O3S.C2HF3O2
MW:646.43
EINECS:
Product Categories:
Mol File:2805804-54-8.mol
CP-547632 TFA Structure
CP-547632 TFA Chemical Properties
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
CP-547632 TFA Usage And Synthesis
UsesCP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 TFA has antitumor efficacy[1].
in vivo

CP-547632 TFA (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts[1].
CP-547632 TFA (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours[1].

Animal Model:Athymic female mice (CD-1 nu/nu) bearing tumors (75-150 mm in size)[1]
Dosage:6.25, 12.5, 25, 50, 100 mg/kg
Administration:PO; daily; 10-24 days
Result:Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
Animal Model:Female athymic mice bearing H-Ras tumor[1]
Dosage:50 mg/kg
Administration:Oral
Result:A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.
IC 50VEGFR2: 11 nM (IC50); FGFR: 9 nM (IC50)
References[1] Beebe JS, et al. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Cancer Res. 2003 Nov 1;63(21):7301-9. PMID:14612527
CP-547632 TFA Preparation Products And Raw materials
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