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| | 17-GMP-APA-GA Basic information |
| | 17-GMP-APA-GA Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml). | | form | solid | | color | Purple | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be made fresh and used within 1 working day. |
| | 17-GMP-APA-GA Usage And Synthesis |
| Description | 17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example. | | Uses | 17-GMP-APA-GA is an analog of geldanamycin(G304500) with modified linker for coupling proteins/antibodies for the preparation of immunoconjugates. | | References | [1] RAYA MANDLER. Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.[J]. Cancer research, 2004, 64 4: 1460-1467. DOI:10.1158/0008-5472.can-03-2485
[2] RAYA MANDLER. Modifications in Synthesis Strategy Improve the Yield and Efficacy of Geldanamycin−Herceptin Immunoconjugates[J]. Bioconjugate Chemistry Bioconjugate, 2002, 13 4: 786-791. DOI:10.1021/bc010124g
[3] R MANDLER. Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines.[J]. JNCI Journal of the National Cancer Institute, 2000, 92 19: 1573-1581. DOI:10.1093/jnci/92.19.1573 |
| | 17-GMP-APA-GA Preparation Products And Raw materials |
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