| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
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| | AZD8154 Basic information |
| Product Name: | AZD8154 | | Synonyms: | AZD8154;1H-Isoindol-1-one, 2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-5-[4-methyl-2-[[6-(2-oxo-1-pyrrolidinyl)-2-pyridinyl]amino]-5-thiazolyl]-7-(methylsulfonyl)- | | CAS: | 2215022-45-8 | | MF: | C27H29N5O4S2 | | MW: | 551.68 | | EINECS: | | | Product Categories: | | | Mol File: | 2215022-45-8.mol |  |
| | AZD8154 Chemical Properties |
| Boiling point | 898.9±75.0 °C(Predicted) | | density | 1.437±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (45.32 mM; Need ultrasonic) | | pka | 2.82±0.10(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | AZD8154 Usage And Synthesis |
| Uses | AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. | | IC 50 | PI3Kγ | | References | [1] Sadiq MW, et al. Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. Br J Clin Pharmacol. 2021 Jun 28. DOI:10.1111/bcp.14956 |
| | AZD8154 Preparation Products And Raw materials |
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