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| | 2-bromo-3-methylacetophenone Basic information |
| | 2-bromo-3-methylacetophenone Chemical Properties |
| Boiling point | 120-122 °C(Press: 1.5 Torr) | | density | 1.416±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | Colorless to light yellow ＜47℃ Solid,＞48℃ Liquid | | InChI | InChI=1S/C9H9BrO/c1-7-3-2-4-8(5-7)9(11)6-10/h2-5H,6H2,1H3 | | InChIKey | BANFRNTVKCHZDE-UHFFFAOYSA-N | | SMILES | C(=O)(C1=CC=CC(C)=C1)CBr |
| | 2-bromo-3-methylacetophenone Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-bromo-1-(3-methylphenyl)ethyl-1-one from 1-(bromoethynyl)-3-methylbenzene: A mixed solution of 1-(bromoethynyl)-3-methylbenzene (0.5 mmol), AgF (5 mol%), and water (1 eq.) in TFA (1 mL) was stirred and reacted for 6 hours at 40 °C. Upon completion of the reaction, the TFA was recovered by distillation for reuse. The reaction mixture was purified by column chromatography to afford the target product 2-bromo-1-(3-methylphenyl)ethyl-1-one. | | References | [1] European Journal of Organic Chemistry, 2016, vol. 2016, # 1, p. 116 - 121
[2] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[3] Journal of Organic Chemistry, 2013, vol. 78, # 18, p. 9190 - 9195
[4] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
[5] Tetrahedron, 2016, vol. 72, # 27-28, p. 3818 - 3822 |
| | 2-bromo-3-methylacetophenone Preparation Products And Raw materials |
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