| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
|
| | 2-(Pyrimidin-5-yl)phenol Basic information |
| | 2-(Pyrimidin-5-yl)phenol Chemical Properties |
| Melting point | 173°C | | Boiling point | 336.2±25.0 °C(Predicted) | | density | 1.233±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 8.75±0.35(Predicted) | | form | powder |
| | 2-(Pyrimidin-5-yl)phenol Usage And Synthesis |
| Uses | 2-(Pyrimidin-5-yl)phenol is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-Fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maitiμs lab th at promote site selectivity without the inclusion of additional synthetic steps.
2-(Pyrimidin-5-yl)phenol is an effective TDG for meta directed C-H functionalization of substitutes with a variety of electron withdrawing functional groups, with high selectivity. |
| | 2-(Pyrimidin-5-yl)phenol Preparation Products And Raw materials |
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