1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- manufacturers
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| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Basic information |
| Product Name: | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- | | Synonyms: | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-;2-(2,6-dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione;Thalidomide-5-propargyl;Thalidomide-5-O-propargyl;2-(2,6-Dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione | | CAS: | 2226303-74-6 | | MF: | C16H12N2O5 | | MW: | 312.28 | | EINECS: | | | Product Categories: | | | Mol File: | 2226303-74-6.mol |  |
| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Chemical Properties |
| Boiling point | 587.6±50.0 °C(Predicted) | | density | 1.469±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, stored under nitrogen | | form | Solid | | pka | 10.70±0.40(Predicted) | | color | White to off-white |
| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Usage And Synthesis |
| Uses | Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1]. | | IC 50 | Cereblon | | References | [1] Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10. |
| | 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Preparation Products And Raw materials |
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