Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl-

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Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl- Basic information
Product Name:Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl-
Synonyms:Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl-;PPARγ modulator-1
CAS:1415321-54-8
MF:C34H40N2O4
MW:540.69
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Mol File:1415321-54-8.mol
Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl- Structure
Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl- Chemical Properties
Boiling point 760.1±60.0 °C(Predicted)
density 1.12±0.1 g/cm3(Predicted)
pka3.27±0.10(Predicted)
Safety Information
MSDS Information
Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl- Usage And Synthesis
UsesAnticancer agent 183 (example 48) is a non-agonistic PPARG modulator. Anticancer agent 183 has a high affinity to PPARG (PPARγ). Anticancer agent 183 inhibits kinase-mediated phosphorylation of PPARG. Anticancer agent 183 can used for research on metabolic diseases to avoid side effects[1].
IC 50PPAR-γ
References[1] Theodore Mark Kamenecka, et al. N-benzylindole modulators of pparg. 2012.
Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl- Preparation Products And Raw materials
Tag:Propanoic acid, 2-[3-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-2-methyl-(1415321-54-8) Related Product Information
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