Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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0513-66337626 18051384581 |
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sales@chemhifuture.com |
Products Intro: |
Product Name:UBX1325 CAS:2271269-01-1 Purity:98%HPLC Package:10mg,100mg,500mg,1g,2g,5g,10g,more
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Company Name: |
Chengdu Peter-like Biotechnology Co., Ltd.
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Tel: |
028-81700200 13308200041 |
Email: |
2851167782@qq.com |
Products Intro: |
Product Name:UBX1325 CAS:2271269-01-1 Purity:HPLC>=98% 现货 Package:5mg10mg20mg50mg100mg500mg1g2g等应客户需求包装
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Company Name: |
Aikon International Limited
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025-58851090 13408877820 |
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2850281427@qq.com |
Products Intro: |
CAS:2271269-01-1 Purity:95% Package:1g;5g;10g
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| 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-(1-methylethyl)-4-[3-[4-[4-[[[4-[[(1R)-1-[(phenylthio)methyl]-3-[4-(phosphonooxy)-1-piperidinyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]- Basic information |
| 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-(1-methylethyl)-4-[3-[4-[4-[[[4-[[(1R)-1-[(phenylthio)methyl]-3-[4-(phosphonooxy)-1-piperidinyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]- Chemical Properties |
Boiling point | 1145.0±75.0 °C(Predicted) | density | 1.45±0.1 g/cm3(Predicted) | form | Solid | pka | 1.79±0.10(Predicted) | color | White to light yellow |
| 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-(1-methylethyl)-4-[3-[4-[4-[[[4-[[(1R)-1-[(phenylthio)methyl]-3-[4-(phosphonooxy)-1-piperidinyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]- Usage And Synthesis |
Uses | UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1]. | References | [1] Pamela Tsuruda, et al. UBX1325, a small molecule inhibitor of Bcl-xL, attenuates vascular dysfunction in two animal models of retinopathy. Investigative Ophthalmology & Visual Science June 2021,Volume 62, Issue 8 |
| 1H-Pyrrole-3-carboxylic acid, 5-(4-chlorophenyl)-2-methyl-1-(1-methylethyl)-4-[3-[4-[4-[[[4-[[(1R)-1-[(phenylthio)methyl]-3-[4-(phosphonooxy)-1-piperidinyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]amino]phenyl]-1-piperazinyl]phenyl]- Preparation Products And Raw materials |
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