Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-

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Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- Suppliers list
Company Name: TargetMol Chemicals Inc.  
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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- manufacturers

  • R1498
  • R1498 pictures
  • $2500.00
  • 2026-04-21
  • CAS:303196-31-8
  • Purity:
  • Supply Ability: 10g
Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- Basic information
Product Name:Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-
Synonyms:Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-;R 1498;R1498;R-1498
CAS:303196-31-8
MF:C18H15ClN4O
MW:338.79
EINECS:
Product Categories:
Mol File:303196-31-8.mol
Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- Structure
Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- Chemical Properties
Boiling point 560.8±50.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
pka17.90±0.40(Predicted)
Safety Information
MSDS Information
Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- Usage And Synthesis
DescriptionR1498 is an inhibitor of cyclin-dependent kinase 2 (CDK2). It is well-tolerated and orally active for hepatocellular carcinoma and gastric cancer treatment and acts via targeting angiogenesis and mitosis pathways.
UsesR1498 is a multi-target kinase inhibitor with anti-angiogenic and anti-proliferative activities. R1498 mainly targets targets such as Aurora kinase and VEGFR2, which are associated with tumor development. R1498 showed moderate in vitro growth inhibition in a variety of tumor cells, with IC50 values in the micromolar range. R1498 showed anti-tumor efficacy superior to sorafenib in a variety of gastric cancer and hepatocellular carcinoma xenograft models, with tumor growth inhibition rates exceeding 80%, and tumor shrinkage was observed in some models. R1498 showed a 10-30% tumor shrinkage rate in three xenograft models derived from human primary gastric cancer tumors, further demonstrating its inhibitory potential. R1498 effectively inhibited Aurora A activity in vivo and reduced tumor vascularization[1].
References[1] Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways DOI:10.1371/journal.pone.0065264
Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl- Preparation Products And Raw materials
Tag:Pyrazolo[3,4-b][1,4]benzodiazepine, 5-(2-chlorophenyl)-1,2-dihydro-7-methoxy-3-methyl-(303196-31-8) Related Product Information
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