| Company Name: |
Shanghai Boyle Chemical Co., Ltd.
|
| Tel: |
021-50182298 021-50180596 |
| Email: |
sales@boylechem.com |
| Products Intro: |
Product Name:tert-butyl 2-cyanopyridin-4-ylcarbaMate
CAS:262295-94-3
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Email: |
sales@leadmedpharm.com |
| Products Intro: |
Product Name:tert-butyl 2-cyanopyridin-4-ylcarbamate
CAS:262295-94-3
Purity:95% Package:1g;5g;25g;100g
|
|
| | Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Basic information |
| Product Name: | Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) | | Synonyms: | N-(2-cyano-4-pyridinyl)carbamic acid tert-butyl ester;(2-Cyano-pyridin-4-yl)-carbamic acid tert-butyl ester;Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI);tert-butyl 2-cyanopyridin-4-ylcarbamate;Carbamic acid, N-(2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester;Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester;tert-butyl N-(2-cyano-4-pyridyl)carbamate;4-(Boc-amino)picolinonitrile | | CAS: | 262295-94-3 | | MF: | C11H13N3O2 | | MW: | 219.24 | | EINECS: | | | Product Categories: | N-BOC | | Mol File: | 262295-94-3.mol |  |
| | Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis |
| Synthesis | GENERAL STEPS: To a solution of 4-bromopyridine-2-carbonitrile (20 g, 109.29 mmol) in 1,4-dioxane (300 mL) was added sequentially Pd(OAc)2 (2.98 g, 13.27 mmol), XPhos (18.9 g, 39.34 mmol) and Cs2CO3 (50.3 g, 154.38 mmol). The reaction mixture was stirred at 100 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and solid impurities were removed by filtration. The filtrate was concentrated under reduced pressure and purified by fast column chromatography (eluent: EtOAc/petroleum ether = 1/3, v/v) to afford the target compound tert-butyl (2-cyanopyridin-4-yl)carbamate as a yellow solid (23 g, 95% yield).LC-MS (ES, m/z): 220 [M + H]+. 1H NMR (300 MHz, CDCl3) : δ 8.49 (d, J = 5.6 Hz, 1H), 7.87 (d, J = 2.2 Hz, 1H), 7.43 (dd, J = 5.6, 2.2 Hz, 1H), 6.90 (s, 1H), 1.54 (s, 9H) ppm. | | References | [1] Patent: US2016/243100, 2016, A1. Location in patent: Paragraph 0257-0258 |
| | Carbamic acid, (2-cyano-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials |
|