Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) manufacturers
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| | Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) Basic information |
| Product Name: | Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) | | Synonyms: | Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI);pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro-;Albb-009270;1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine(SALTDATA: FREE);1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine;1,2,3,4-TETRAHYDROPYRROLO[1,2-A]PYRAZINE 2-BUTENEDIOATE | | CAS: | 71257-38-0 | | MF: | C7H10N2 | | MW: | 122.17 | | EINECS: | | | Product Categories: | AMINETERTIARY | | Mol File: | 71257-38-0.mol | ![Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) Structure](CAS/GIF/71257-38-0.gif) |
| | Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) Chemical Properties |
| Boiling point | 239.6±28.0 °C(Predicted) | | density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 7.40±0.20(Predicted) | | Appearance | Colorless to light yellow Liquid |
| RIDADR | 3265 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 2933998090 |
| | Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine from 2-(1H-pyrrol-1-yl)ethylamine and formaldehyde: 2-(1H-pyrrol-1-yl)ethylamine (2 g, 18 mmol) was dissolved in 40 mL of ethanol, followed by the addition of 40% aqueous formaldehyde (1.5 mL, 18 mmol) and the slow dropwise addition of 1 mL trifluoroacetic acid. The reaction mixture was heated to 50 °C and maintained for 15 minutes, then cooled to room temperature and stirred continuously for 12 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure, diluted by adding 50 mL of ethyl acetate, and the organic phase was washed with 50 mL of saturated sodium bicarbonate solution, followed by drying with anhydrous sodium sulfate and filtration. Finally, the filtrate was concentrated by decompression to afford 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine (1.60 g, 72.7% yield) as a light yellow oil. | | References | [1] Patent: EP2604610, 2013, A1. Location in patent: Paragraph 0082; 0084
[2] Patent: US2013/131068, 2013, A1. Location in patent: Paragraph 0105
[3] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 75
[4] Patent: CN108250128, 2018, A. Location in patent: Paragraph 0787; 0789; 0792; 0793
[5] Patent: US2009/186899, 2009, A1. Location in patent: Page/Page column 37; 41 |
| | Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro- (9CI) Preparation Products And Raw materials |
| Raw materials | Pyrrolo[1,2-a]pyrazine, 3,4-dihydro- (9CI)-->2-(1H-PYRROL-1-YL)-1-ETHANAMINE-->Formaldehyde-->Ethanol-->Trifluoroacetic acid | | Preparation Products | Pyrrolo[1,2-a]pyrazine, 2-acetyl-1,2,3,4-tetrahydro- (9CI)-->1-benzyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine |
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