L-161,982

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L-161,982 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:L-161982
CAS:147776-06-5
Purity:99.91% Package:1mg;72USD|5mg;198USD|10mg;322USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203
Email: info@chemextension.com
Products Intro: Product Name:L 161982
CAS:147776-06-5
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:L-161,982
CAS:147776-06-5
Purity:>=98% Package:$249.9/10mg;$769.9/50mg;Bulk package Remarks:98%
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:L-161,982;N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoroMethyl)phenyl]-4H-1,2,4-triazol-4-yl]Methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-Methyl-2-thiophenecarboxaMide
CAS:147776-06-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Email: isunpharm@qq.com
Products Intro: Product Name:L-161,982
CAS:147776-06-5
Purity:98% (HPLC) Package:5MG; 25MG; 100MG; 1G

L-161,982 manufacturers

  • L-161982
  • L-161982 pictures
  • $64.00 / 1mg
  • 2026-04-20
  • CAS:147776-06-5
  • Min. Order:
  • Purity: 99.91%
  • Supply Ability: 10g
L-161,982 Basic information
Product Name:L-161,982
Synonyms:L-161,982;N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]- 2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide;N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide;2-Thiophenecarboxamide, N-[[4'-[[3-butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-;L-161,982 >=98% (HPLC);colon,cancer,phosphorylation,prostaglandin,Prostaglandin Receptor,L161982,arthritis,inhibit,proliferation,L 161982,L-161982,Inhibitor;L-161,982, EP4 receptor antagonist;L-161982, 10 mM in DMSO
CAS:147776-06-5
MF:C32H29F3N4O4S2
MW:654.72
EINECS:
Product Categories:Prostanoid receptor and related
Mol File:147776-06-5.mol
L-161,982 Structure
L-161,982 Chemical Properties
density 1.37±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
form powder
pka4.57±0.10(Predicted)
color white to beige
InChIKeyMMDNKTXNUZFVKD-UHFFFAOYSA-N
SMILESFC(F)(F)c1c(cccc1)[n]2nc([n]([c]2=O)Cc3ccc(cc3)c4c(cccc4)[S](=O)(=O)NC(=O)c5[s]ccc5C)CCCC
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
L-161,982 Usage And Synthesis
DescriptionProstaglandin E2 (PGE2) exerts its effects through four separate G coupled-protein receptors (EP1-4). L-161,982 is a potent and selective EP4 receptor antagonist. It demonstrates selective binding to human EP4 receptors with a Ki value of 0.024 μM compared to other receptors of the prostanoid family, EP1, EP2, EP3, DP, FP, and IP, with Ki values of 17, 23, 1.9, 5.1, 5.6, and 6.7 μM, respectively. L-161,982 at 10 mg/kg/day suppresses PGE2-stimulated bone formation in young rats and at 100 nM reverses the anti-inflammatory action of PGE2 in LPS-activated human macrophages. At 10 μM L-161982 blocks PGE2-induced cell proliferation in HCA-7 colon cancer cells.
UsesL-161,982 is an EP4 receptor antagonist, which blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
DefinitionChEBI: N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methyl-2-thiophenecarboxamide is a member of biphenyls.
Biological ActivityEP 4 receptor antagonist that is selective over all other members of the prostanoid receptor family (K i values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μ M for human EP 4 , TP, EP 3 , DP, FP, IP, EP 1 and EP 2 receptors respectively). Suppresses PGE 2 -induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice.
Biochem/physiol ActionsL-161,982 is a potent EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively.
storageDesiccate at +4°C
References[1] M. MACHWATE. Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).[J]. Molecular Pharmacology, 2001, 60 1 1: 36-41. DOI: 10.1124/mol.60.1.36
[2] KIYOSHI TAKAYAMA. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor.[J]. The Journal of Biological Chemistry, 2002, 277 46: 44147-44154. DOI: 10.1074/jbc.m204810200
[3] DURGA PRASAD CHERUKURI . The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells[J]. Experimental cell research, 2007, 313 14: Pages 2969-2979. DOI: 10.1016/j.yexcr.2007.06.004
[4] ANG LIN. TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells[J]. Oncoimmunology, 2015, 5 1. DOI: 10.1080/2162402x.2015.1074376
L-161,982 Preparation Products And Raw materials
Tag:L-161,982(147776-06-5) Related Product Information
CJ-21058 GW 627368X CJ-42794 PROSTAGLANDIN F1ALPHA Latanoprost Misoprostol Acid ONO-AE3-208 13,14-DIHYDROPROSTAGLANDIN E1 Grapiprant Prostaglandin F2a PROSTAGLANDIN D2 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID 11BETA-PROSTAGL AND IN F2ALPHA LEUKOTRIENE B4 DIMETHYL AMIDE LEUKOTRIENE D4 CJ 033466 L-161,982 4,5-DIETHYL-2,4-DIHYDRO 1,2,4-TRIAZOL-3 ONE