2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1)

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2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) Basic information
Product Name:2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1)
Synonyms:2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1);Ezurpimtrostat hydrochloride;Ezurpimtrostat hydrochloride（GNS561 hydrochloride）
CAS:1914148-73-4
MF:C25H32Cl2N4
MW:459.46
EINECS:
Product Categories:
Mol File:1914148-73-4.mol
2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) Structure
2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and heat to 60°C)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) Usage And Synthesis
UsesEzurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1].
in vivo

Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1].

References[1] Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1.
2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1) Preparation Products And Raw materials
Tag:2-Quinolinamine, N-[(4-chlorophenyl)methyl]-4-[4-[(1,1-dimethylethyl)amino]-1-piperidinyl]-, hydrochloride (1:1)(1914148-73-4) Related Product Information
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