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| | Histatin 5 Basic information |
| Product Name: | Histatin 5 | | Synonyms: | Histatin 5 (synthetic human re-Hst5);Human histatin 5;Peptide F-A (human parotid saliva);L-Tyrosine, L-α-aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-;L-α-Aspartyl-L-seryl-L-histidyl-L-alanyl-L-lysyl-L-arginyl-L-histidyl-L-histidylglycyl-L-tyrosyl-L-lysyl-L-arginyl-L-lysyl-L-phenylalanyl-L-histidyl-L-α-glutamyl-L-lysyl-L-histidyl-L-histidyl-L-seryl-L-histidyl-L-arginylglycyl-L-tyrosine | | CAS: | 115966-68-2 | | MF: | C133H195N51O33 | | MW: | 3036.3 | | EINECS: | | | Product Categories: | | | Mol File: | 115966-68-2.mol |  |
| | Histatin 5 Chemical Properties |
| density | 1.57±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | Sequence | Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr |
| | Histatin 5 Usage And Synthesis |
| Uses | Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. | | References | [1] Gusman H, et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontaldisease. Infect Immun. 2001 Mar;69(3):1402-8. DOI:10.1128/IAI.69.3.1402-1408.2001
[2] Helmerhorst EJ, et al. The human salivary peptide histatin 5 exerts its antifungal activity through the formation ofreactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42. DOI:10.1073/pnas.141366998 |
| | Histatin 5 Preparation Products And Raw materials |
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