2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]-

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2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- Basic information
Product Name:2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]-
Synonyms:2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]-;STAT6-IN-2;(R)-4-(1-Methyl-1H-indol-2-yl)-N2-(3-methylbutan-2-yl)-N6-(2-(pyridin-2-yl)ethyl)pyridine-2,6-dicarboxamide;2-N-[(2R)-3-methylbutan-2-yl]-4-(1-methylindol-2-yl)-6-N-[2-(pyridin-2-yl)ethyl]pyridine-2,6-dicarboxamide - [AC77770]
CAS:1355594-85-2
MF:C28H31N5O2
MW:469.58
EINECS:
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Mol File:1355594-85-2.mol
2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- Structure
2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- Chemical Properties
Boiling point 699.6±55.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
pka13.25±0.46(Predicted)
form Solid
color White to light yellow
Safety Information
MSDS Information
2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- Usage And Synthesis
UsesSTAT6-IN-2 (Compound R-84) is a STAT6 inhibitor that can inhibit the tyrosine phosphorylation of STAT6. STAT6-IN-2 can also inhibit the secretion of eotaxin-3. STAT6-IN-2 can be used in the research of immune diseases and allergic inflammatory diseases such as asthma[1].
References[1] Zhou L, et.al. STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem. 2012 Jan 15;20(2):750-8. DOI:10.1016/j.bmc.2011.12.006
2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]- Preparation Products And Raw materials
Tag:2,6-Pyridinedicarboxamide, N2-[(1R)-1,2-dimethylpropyl]-4-(1-methyl-1H-indol-2-yl)-N6-[2-(2-pyridinyl)ethyl]-(1355594-85-2) Related Product Information
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