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| | 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Basic information |
| Product Name: | 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE | | Synonyms: | DI(HYDROXYETHYL)PIPERAZINE;AKOS BB-4936;2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL;1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE;1,4-BIS(2-HYDROXYETHYL)PIPERAZINE;1,4-PIPERAZINEDIETHANOL;1,4-Bis(beta-hydroxyethyl)piperazine;1,4-Di(2-hydroxyethyl)piperazine | | CAS: | 122-96-3 | | MF: | C8H18N2O2 | | MW: | 174.24 | | EINECS: | 204-586-0 | | Product Categories: | PIPERIDINE | | Mol File: | 122-96-3.mol |  |
| | 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties |
| Melting point | 133.5-136 °C(lit.) | | Boiling point | 215-220 °C50 mm Hg(lit.) | | density | 1.097 | | vapor pressure | 0.004Pa at 20℃ | | refractive index | 1.4540 (estimate) | | Fp | 166℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 14.66±0.10(Predicted) | | form | powder to crystal | | color | White to Almost white | | Water Solubility | Soluble in water. | | InChI | 1S/C8H18N2O2/c11-7-5-9-1-2-10(4-3-9)6-8-12/h11-12H,1-8H2 | | InChIKey | VARKIGWTYBUWNT-UHFFFAOYSA-N | | SMILES | OCCN1CCN(CCO)CC1 | | LogP | -1.92 at 20℃ | | CAS DataBase Reference | 122-96-3(CAS DataBase Reference) | | EPA Substance Registry System | 1,4-Piperazinediethanol (122-96-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | WGK Germany | 3 | | RTECS | TL3675000 | | TSCA | TSCA listed | | HS Code | 2933.59.9500 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Dam. 1 |
| | 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | 1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases. | | Flammability and Explosibility | Not classified | | Synthesis | The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows:
Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions
Operational steps:
1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 .
2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin).
3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine. | | References | [1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952, |
| | 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Preparation Products And Raw materials |
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