2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-

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2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Suppliers list
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2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- manufacturers

  • MAO-B-IN-5
  • MAO-B-IN-5 pictures
  • $93.00
  • 2026-07-14
  • CAS:849909-77-9
  • Purity: 97.68%
  • Supply Ability: 10g
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Basic information
Product Name:2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-
Synonyms:2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-;MAO B IN 5,MAOBIN5;MAO-B-IN-5
CAS:849909-77-9
MF:C19H21FN2O2
MW:328.38
EINECS:
Product Categories:
Mol File:849909-77-9.mol
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Structure
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties
Boiling point 509.2±50.0 °C(Predicted)
density 1.237±0.06 g/cm3(Predicted)
pka16.07±0.20(Predicted)
Safety Information
MSDS Information
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Usage And Synthesis
UsesMAO-B-IN-5 is a potent, selective and orally active MAO-B inhibitor with an IC50 of 0.204 μM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD)[1].
in vivo

MAO-B-IN-5 (1 mg/kg, i.v.; 5 mg/kg, p.o.) shows oral bioavailability in rats (F=13.6%)[1].
Pharmacokinetic Parameters of MAO-B-IN-5 in SD rats[1].

CompoundRouteDose (mg/kg)Cmax (ng/mL)AUCt (ng·h/mL)T1/2 (h)Vss (h)Cl (mL/min/kg)F (%)
D0iv18093470.371.1147.1/
po51632841.27//16.3
SD rats; 1 mg/kg, i.v.; 5 mg/kg, p.o.[1].
Animal Model:SD rats[1]
Dosage:1, 5 mg/kg
Administration:1 mg/kg, i.v.; 5 mg/kg, p.o.
Result:Showed oral bioavailability in rats (F=16.3%).
IC 50MAO-B: 34.190 μM (IC50); MAO-A: 0.204 μM (IC50)
References[1] Wang Z,et al. Enhancing monoamine oxidase B inhibitory activity via chiral fluorination: Structure-activity relationship, biological evaluation, and molecular docking study. Eur J Med Chem. 2022; 228:114025. DOI:10.1016/j.ejmech.2021.114025
2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials
Tag:2-Pyrrolidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)-(849909-77-9) Related Product Information
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