CAM833 manufacturers
- CAM 833
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- $1520.00 / 25mg
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2025-09-17
- CAS:2758364-02-0
- Min. Order:
- Purity: 99.83%
- Supply Ability: 10g
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| | CAM833 Chemical Properties |
| Boiling point | 868.2±65.0 °C(Predicted) | | density | 1.398±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in DMSO and to 5 mM in ethanol | | form | Solid | | pka | 11.12±0.46(Predicted) | | color | White to off-white |
| | CAM833 Usage And Synthesis |
| Description | CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization[1]. CAM833 (3.125-50 μM; 24 h) causes a concentration-dependent decrease in RAD51 foci and subsequent increase in DNA damage[1].
CAM833 (25 μM) inhibits RAD51 molecular clustering at DNA damage sites[1].
CAM833 (0-50 μM) inhibits DNA repair by homologous recombination[1].
CAM833 (20 μM; 0-72 h) potentiates radiation-induced cell-cycle arrest and increases apoptosis over time[1].
CAM833 (10 μM) causes a dose-dependent growth inhibition that is enhanced when combined with ionizing radiation[1].
CAM833 (20 μM; 96 h) potentiates the growth suppressive effect of PARP1 inhibition in BRCA2 wild-type cells[1]. Cell Cycle Analysis[1] | | Uses | CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and RAD51 with a Kd of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833 increases the progression of G2/M-arrested cells into apoptosis[1]. | | storage | Store at -20°C | | References | [1] Scott DE, et al. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. DOI:10.1016/j.chembiol.2021.02.006 |
| | CAM833 Preparation Products And Raw materials |
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