硝米芬
| 中文名称 | 硝米芬 |
|---|---|
| 中文同义词 | 硝米芬;化合物 T16330;化合物 NITROMIFENE |
| 英文名称 | Nitromifene |
| 英文同义词 | Nitromifene;1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine;Nitromifen;CI628;Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-;1-[2-[4-[1-(4-Methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine |
| CAS号 | 10448-84-7 |
| 分子式 | C27H28N2O4 |
| 分子量 | 444.52 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 10448-84-7.mol |
| 结构式 |  |
硝米芬 性质
| 熔点 | 118-120 °C(Solv: methanol (67-56-1)) |
|---|---|
| 沸点 | 576.7±50.0 °C(Predicted) |
| 密度 | 1.183±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.52±0.20(Predicted) |
Nitromifene 是一个雌激素受体 (ER) 拮抗剂。
ER
Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase.