Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-

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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Suppliers list
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CAS:2272904-53-5
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Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Basic information
Product Name:Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-
Synonyms:Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-;Zasocitinib;NDI-034858(Zasocitinib);Zasocitinib，NDI-034858，TAK 279;N-((1R,2R)-2-methoxycyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide;N-[(1R,2R)-2-Methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo-2H-[1,2’-bipyridin]-3-yl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide;TAK 279;N-((1R,2R)-2-Methoxy-cyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)-1H-pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS:2272904-53-5
MF:C23H24N8O3
MW:460.49
EINECS:
Product Categories:
Mol File:2272904-53-5.mol
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Structure
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Chemical Properties
density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Acetonitrile: Soluble
DMSO: Soluble
form Solid
pka10.37±0.40(Predicted)
color Off-white to light yellow
InChIKeyBWINBHTTZLVXGT-NVXWUHKLSA-N
SMILESC12=C(C(N[C@@H]3CC[C@H]3OC)=O)C=NN1C(NC)=CC(NC1=CC=CN(C3=NC=CC=C3)C1=O)=N2
Safety Information
MSDS Information
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Usage And Synthesis
UsesZasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].
References[1] Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.
[2] SILVANA LEIT, CRAIG E. MASSE   Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279[J]. Journal of Medicinal Chemistry, 2023, 66 15: 10473-10496. DOI: 10.1021/acs.jmedchem.3c00600
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]- Preparation Products And Raw materials
Tag:Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-(2272904-53-5) Related Product Information