2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)-

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2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Basic information
Product Name:2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Synonyms:2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)-;sacibertinib
CAS:1351941-69-9
MF:C32H31ClN6O4
MW:599.08
EINECS:
Product Categories:
Mol File:1351941-69-9.mol
2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Structure
2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Chemical Properties
Boiling point 803.7±65.0 °C(Predicted)
density 1.37±0.1 g/cm3(Predicted)
pka12.13±0.43(Predicted)
Safety Information
MSDS Information
2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Usage And Synthesis
UsesSacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
IC 50EGFR-TK phosphorylation: 110 nM (EC50); HER2: 244 nM (EC50)
References[1] Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138)
[2] International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.
2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)- Preparation Products And Raw materials
Tag:2-Butenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinolinyl]-4-(dimethylamino)-, (2E)-(1351941-69-9) Related Product Information
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