Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)-

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Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)- Basic information
Product Name:Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)-
Synonyms:Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)-;KRAS G12C inhibitor 56
CAS:2749963-77-5
MF:C32H39N7O4S
MW:617.76
EINECS:
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Mol File:2749963-77-5.mol
Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)- Structure
Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)- Chemical Properties
Boiling point 781.1±60.0 °C(Predicted)
density 1.34±0.1 g/cm3(Predicted)
pka9.33±0.40(Predicted)
Safety Information
MSDS Information
Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)- Usage And Synthesis
UsesKRAS G12C inhibitor 56 (compound IC-6) is a potent SOS1 inhibitor with an IC50 of 1.6 nM. KRAS G12C inhibitor 56 can be used in cancer research[1].
References[1] Jason ABBOTT, et al. Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer. Patent WO2021245051A1.
Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)- Preparation Products And Raw materials
Tag:Benzo[b]thiophene-3-carbonitrile, 2-amino-4,5,6,7-tetrahydro-4-methyl-4-[5-[4-[(1S)-1-[(2S)-1-methyl-2-pyrrolidinyl]ethoxy]-6-[[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]oxy]-2-pyrimidinyl]-3-isoxazolyl]-, (4S)-(2749963-77-5) Related Product Information
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