| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:C3
CAS:2286257-25-6
Purity:98% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:C3
CAS:2286257-25-6
Package:1removed
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:C3
CAS:2286257-25-6
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:C3
CAS:2286257-25-6
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| | 2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Basic information |
| | 2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties |
| Boiling point | 497.9±45.0 °C(Predicted) | | density | 1.269±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMF: 15 mg/ml,DMSO: 2 mg/ml,Ethanol: 2 mg/ml | | form | A crysalline solid | | pka | 16.07±0.20(Predicted) |
| | 2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Usage And Synthesis |
| Uses | MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC50 of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research[1]. | | Biological Activity | C3 is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 0.021 μM).1 It is selective for MAO-B over MAO-A (IC50 = 26.8 μM). C3 (0.1, 1, and 3 mg/kg) prevents MPTP-induced decreases in brain dopamine levels in mice. | | IC 50 | MAO-B: 0.021 μM (IC50); MAO-A: 26.805 μM (IC50) | | References | 1.Jin, C.-F., Wang, Z.-Z., Chen, K.-Z., et al.Computational fragment-based design facilitates discovery of potent and selective monoamine oxidase-B (MAO-B) inhibitorJ. Med. Chem.63(23)15021-15036(2020) |
| | 2-Azetidinecarboxamide, 1-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials |
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