7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐 CAS#: 194093-42-0

7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐

生物活性靶点体内研究用途与合成方法 MSDS 7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐价格(试剂级) 上下游产品信息

中文名称	7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐
中文同义词	PUMOSETRAG 盐酸盐;7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐;化合物 T16683;化合物 PUMOSETRAG HYDROCHLORIDE;化合物:Pumosetrag Hydrochloride (MKC-733) CAS:194093-42-0;化合物：Pumosetrag Hydrochloride (MKC-733) CAS:194093-42-0
英文名称	N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride
英文同义词	N-[(8R)-1-azabicyclo[2.2.2]oct-8-yl]-2-oxo-9-thia-5-azabicyclo[4.3.0]n ona-3,7,10-triene-3-carboxamide hydrochloride;7-Oxo-N-[3(R)-quinuclidinyl]-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamide hydrochloride;Pumosetrag hydrochloride;PuMosetrag hydrochloride MKC-733;DDP733;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxamide hydrochloride;MKC-733 >=98% (HPLC);Pumosetrag Hydrochloride/MKC-733/DDP-733
CAS号	194093-42-0
分子式	C15H18ClN3O2S
分子量	339.84
EINECS号
相关类别
Mol文件	194093-42-0.mol
结构式

7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐性质

储存条件	2-8°C
溶解度	H2O：可溶，25mg/mL，澄清
形态	粉末
颜色	白色至米色
旋光度 (Optical Rotation)	[α]/D -15 to -20°, c = 1 in H2O
水溶解性	H2O: 25mg/mL, clear
InChI	1S/C15H17N3O2S.ClH/c19-13-10(7-16-11-3-6-21-14(11)13)15(20)17-12-8-18-4-1-9(12)2-5-18;/h3,6-7,9,12H,1-2,4-5,8H2,(H,16,19)(H,17,20);1H/t12-;/m0./s1
InChIKey	XGVADZZDFADEOO-YDALLXLXSA-N
SMILES	O=C(C1=CNC(C=CS2)=C2C1=O)N[C@@H]3C4CCN(CC4)C3.Cl

7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐用途与合成方法

生物活性

Pumosetrag Hydrochloride (MKC-733; DDP-733) 是一种口服可用的 5-HT3 部分激动剂，可用于肠易激综合征和胃食管反流病的研究。

靶点

5-HT ₃ Receptor

体内研究

Pumosetrag displays both regional and species specificities. Pumosetrag has a lower efficacy than 5-HT in the rat jejunum, ileum and distal colon; however, it has similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Pumosetrag shows little to no response in the regions of the mouse intestine. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors. Pumosetrag delays liquid gastric emptying in association with relaxation of the proximal stomach, stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit.

安全信息

WGK Germany	3
存储类别	11 - 可燃固体

MSDS信息

7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/09/15	HY-19650	7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐 Pumosetrag Hydrochloride	194093-42-0	1 mg	500元
2026/09/15	HY-19650	7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐 Pumosetrag Hydrochloride	194093-42-0	5mg	1100元

7-氧代-N-[3(R)-奎宁环基]-4,7-二氢噻吩并[3,2-B]吡啶-6-甲酰胺盐酸盐