(2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione
| 中文名称 | (2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione |
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| 中文同义词 | 莱姆霉素EP杂质C;四环素EP杂质C;化合物 Anhydrotetracycline;金霉素杂质10(金霉素EP杂质J) |
| 英文名称 | (2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione |
| 英文同义词 | (2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione;5a,6-anhydrotetracycline;(1S)-1α-(Dimethylamino)-2,4aα,6,7-tetrahydroxy-4,5-dioxo-11-methyl-1,4a,12,12aα-tetrahydronaphthacene-3-carboxamide;(4S)-4β-Dimethylamino-1,4,4aβ,5,12,12a-hexahydro-3,10,11,12aβ-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide;(4S)-Anhydrotetracycline;3,10,11,12aβ-Tetrahydroxy-4β-(dimethylamino)-6-methyl-1,12-dioxo-1,4,4aβ,5,12,12a-hexahydronaphthacene-2-carboxamide;(4R)-4α-Dimethylamino-1,4,4aβ,5,12,12a-hexahydro-3,10,11,12aβ-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide;4-Epianhydrotetracycline |
| CAS号 | 1665-56-1 |
| 分子式 | C22H22N2O7 |
| 分子量 | 426.42 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1665-56-1.mol |
| 结构式 |  |
(2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione 性质
| 熔点 | 221-222 °C (decomp)(Solv: ethyl acetate (141-78-6)) |
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| 沸点 | 708.6±60.0 °C(Predicted) |
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
| EPA化学物质信息 | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, (4S,4aS,12aS)- (1665-56-1) |
(2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione 用途与合成方法
Anhydrotetracycline (5a(6)-Anhydrotetracycline) 是四环素失活酶小分子抑制剂，对抗四环素类抗生素的酶降解。Anhydrotetracycline 能够在表达四环素破坏酶的全细胞大肠杆菌中拯救四环素活性。