- 2,6-Difluorobenzaldehyde
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- $5.00 / 1KG
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2025-09-25
- CAS:437-81-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 2,6-Difluorobenzaldehyde Basic information |
| | 2,6-Difluorobenzaldehyde Chemical Properties |
| Melting point | 15-17 °C (lit.) | | Boiling point | 82-84 °C/15 mmHg (lit.) | | density | 1.317 g/mL at 25 °C (lit.) | | vapor pressure | 40.1-900hPa at 94.5-189℃ | | refractive index | n20/D 1.502(lit.) | | Fp | 164 °F | | storage temp. | 2-8°C | | form | Liquid | | color | Clear light yellow to bright yellow | | Specific Gravity | 1.317 | | Sensitive | Air Sensitive | | BRN | 1935273 | | InChI | 1S/C7H4F2O/c8-6-2-1-3-7(9)5(6)4-10/h1-4H | | InChIKey | SOWRUJSGHKNOKN-UHFFFAOYSA-N | | SMILES | Fc1cccc(F)c1C=O | | LogP | 1.46 at 25℃ and pH2 | | Surface tension | 73.1mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 437-81-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39-37/39-36/37 | | WGK Germany | 2 | | F | 10-23 | | HazardClass | IRRITANT | | HS Code | 29130000 | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1C |
| | 2,6-Difluorobenzaldehyde Usage And Synthesis |
| Chemical Properties | clear light yellow to bright yellow liquid | | Uses | 2,6-Difluorobenzaldehyde can be used as a reactant to synthesize:
- 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil via one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea.
- 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole by reacting with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.
- (3E)-4-(2,6-Difluorophenyl)-3-buten-2-one by Wittig olefination reaction with acetylmethylidenetriphenyl phosphorane.
- Methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating with methyl thioglycolate in the presence of K2CO3.
| | Synthesis | The general procedure for the synthesis of 2,6-dichlorobenzaldehyde from 2,6-dichlorobenzaldehyde was as follows: first, 34.8 g (0.6 mol) of potassium fluoride (KF) was dissolved in 250 mL of cyclobutanesulfone under nitrogen protection and stirred at 100 °C for 2 h. The water was removed by azeotropic distillation. Subsequently, 20 g (0.11 mol) of 2,6-dichlorobenzaldehyde and 2.8 g (6.68 mmol) of tetraphenylphosphonium bromide were added to this anhydrous mixture and the reaction mixture was heated to 180 °C and kept overnight. Upon completion of the reaction, the solid product was washed with ethyl acetate and the solvent was removed by aqueous pressure evaporation. Finally, the target product 2,6-difluorobenzaldehyde was purified by vacuum evaporation (24 mbar, 85-86 °C) in 77% yield. | | References | [1] Patent: WO2016/102207, 2016, A1. Location in patent: Page/Page column 32
[2] Journal of Fluorine Chemistry, 2004, vol. 125, # 6, p. 1031 - 1038
[3] Chemistry Letters, 1988, # 9, p. 1355 - 1358
[4] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2720 - 2725
[5] Patent: US6103659, 2000, A |
| | 2,6-Difluorobenzaldehyde Preparation Products And Raw materials |
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