4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)-

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4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- manufacturers

  • PBRM1-BD2-IN-5
  • PBRM1-BD2-IN-5 pictures
  • $81.00
  • 2026-07-14
  • CAS:2819989-61-0
  • Purity: 99.55%
  • Supply Ability: 10g
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- Basic information
Product Name:4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)-
Synonyms:4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)-;PBRM1BD2IN5;PBRM1-BD2-IN-5;PBRM1-BD2-IN-5, 10 mM in DMSO
CAS:2819989-61-0
MF:C15H13ClN2O
MW:272.73
EINECS:
Product Categories:
Mol File:2819989-61-0.mol
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- Structure
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- Chemical Properties
Boiling point 542.3±50.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
form Solid
pka12.55±0.40(Predicted)
color White to off-white
Safety Information
MSDS Information
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- Usage And Synthesis
UsesPBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer[1].
References[1] Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13. DOI:10.1021/acs.jmedchem.2c00864
4(1H)-Quinazolinone, 5-chloro-2,3-dihydro-2-(3-methylphenyl)- Preparation Products And Raw materials
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