Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)-

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Email: marketing@targetmol.com

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Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- Basic information
Product Name:Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)-
Synonyms:Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)-;PCSK9 modulator-4
CAS:2476490-20-5
MF:C17H11F2N3O
MW:311.29
EINECS:
Product Categories:
Mol File:2476490-20-5.mol
Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- Structure
Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- Chemical Properties
Boiling point 549.1±58.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka13.33±0.30(Predicted)
Safety Information
MSDS Information
Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- Usage And Synthesis
UsesPCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1].
References[1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678. DOI:10.1016/j.ejmech.2020.112678
Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)- Preparation Products And Raw materials
Tag:Methanone, (7-fluoro-1H-indol-3-yl)(6-fluoro-1-methyl-1H-benzimidazol-2-yl)-(2476490-20-5) Related Product Information
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