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6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- Suppliers list
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| | 6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- Basic information |
| Product Name: | 6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- | | Synonyms: | 6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- | | CAS: | 2692623-89-3 | | MF: | C16H30O2 | | MW: | 254.41 | | EINECS: | | | Product Categories: | | | Mol File: | 2692623-89-3.mol |  |
| | 6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- Chemical Properties |
| solubility | Ethanol: soluble | | form | Liquid | | color | Colorless to light yellow |
| | 6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- Usage And Synthesis |
| Description | cis-6-Hexadecenoic acid-d19 is intended for use as an internal standard for the quantification of cis-6-hexadecenoic acid by GC- or LC-MS. cis-6-Hexadecenoic acid is a monounsaturated fatty acid and is one of the primary fatty acids in human skin.1 cis-6-Hexadecenoic acid levels are increased in isolated sebum from the face and back of patients with acne.2 In contrast, levels are decreased in the non-lesional skin and isolated sebum of atopic dermatitis patients, which correlates with an increase in S. aureus in the sebum.1 It is active against S. aureus in vitro when used at a concentration of 5 μg/ml at pH 5.5.3 cis-6-Hexadecenoic acid disrupts membrane integrity, the proton motive force, increases membrane fluidity, and inhibits the electron transport chain in S. aureus. | | Uses | Sapienic acid-d19 is a deuterated labeled Sapienic acid[1]. Sapienic acid is a fatty acid commonly found on the skin and in mucosa. Sapienic acid has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively[2]. | | References | 1. Takigawa, H., Nakagawa, H., Kuzukawa, M., et al. Deficient production of hexadecenoic acid in the skin is associated in part with the vulnerability of atopic dermatitis patients to colonization by Staphylococcus aureus Dermatology 211(3),240-248(2005).
2. Li, W.-H., Zhang, Q., Flach, C.R., et al. In vitro modeling of unsaturated free fatty acid-mediated tissue impairments seen in acne lesions Arch. Dermatol. Res. 309(7),529-540(2017).
3. Cartron, M.L., England, S.R., Chiriac, A.I., et al. Bactericidal activity of the human skin fatty acid cis-6-hexadecanoic acid on Staphylococcus aureus Antimicrob. Agents Chemother. 58(7),3599-3609(2014). |
| | 6-Hexadecenoic-8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,16-d19 acid, (6Z)- Preparation Products And Raw materials |
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