Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-

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Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Suppliers list
Company Name: Chunchuang (Wuhan) Technology Co., Ltd  
Tel: 15727060112
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Products Intro: Product Name:INDEX NAME NOT YET ASSIGNED
CAS:2858800-98-1
Purity:99+ Package:1g/RMB 10
Company Name: Wuhan Jingkangen Biomedical Technology Co., Ltd  
Tel: 13720134139 086-15871494362 13720134139
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Products Intro: Product Name:OTUB1/USP8-IN-1
CAS:2858800-98-1
Purity:98%
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:OTUB1/USP8 inhibitor 61
CAS:2858800-98-1
Purity:98% Package:1mg;5mg;10mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Products Intro: Product Name:OTUB1/USP8-IN-1
CAS:2858800-98-1
Purity:98.59% Package:1mg/RMB 1120;5mg/RMB 2480;10mg/RMB 3980
Company Name: Sangon Biotech (Shanghai) Co.,Ltd.  
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Products Intro: Product Name:OTUB1/USP8-IN-1, 10 mM in DMSO
CAS:2858800-98-1
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Basic information
Product Name:Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-
Synonyms:OTUB1/USP8-IN-1;Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-;OTUB1/USP8-IN-1, 10 mM in DMSO
CAS:2858800-98-1
MF:C22H16ClFN2O4
MW:426.83
EINECS:
Product Categories:
Mol File:2858800-98-1.mol
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Structure
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Chemical Properties
Boiling point 609.4±65.0 °C(Predicted)
density 1.440±0.06 g/cm3(Predicted)
pka8.72±0.40(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Usage And Synthesis
UsesOTUB1/USP8-IN-1 is a potent dual OTUB1/USP8 inhibitor with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively. OTUB1/USP8-IN-1 can be used in research of cancer[1].
in vivo

OTUB1/USP8-IN-1 (compound 61; 10 nM-10 μM; 72 h) decreases the tumor burden in the H1975 xenograft mouse model[1].

Animal Model:Female BALB/c nude mice with H1975 xenografts (5 weeks of age)[1]
Dosage:5 mg/kg
Administration:Intraperitoneal injection; QD and BID, for 2 weeks
Result:Reduced total tumor weight and average tumor volume in an over twofold with BID dosing.
Animal Model:Female BALB/c nude mice with H1975 xenograft (5 weeks of age)[1]
Dosage:1 and 10 mg/kg
Administration:Intravenous injection (1 mg/kg) and oral administration (10 mg/kg)
Result:1.19
Administrationi.v. (1 mg/kg)p.o. (10 mg/kg)
T1/2 (h)0.831.75
Tmax (h)0.33
Cmax (μg/L)4274
AUC (μg·h/L)13453747
CL (L/h/kg)44
Vdss (L/kg)0.77
References[1] Tan L, et, al. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem. 2022 Oct 11. DOI:10.1021/acs.jmedchem.2c00408
Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]- Preparation Products And Raw materials
Tag:Naphth[2,3-d]oxazole-4,9-dione, 2-[2-chloro-6-fluoro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-(2858800-98-1) Related Product Information