5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)-

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5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- Basic information
Product Name:5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)-
Synonyms:5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)-
CAS:2839311-21-4
MF:C18H19N7OS
MW:381.45
EINECS:
Product Categories:
Mol File:2839311-21-4.mol
5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- Structure
5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- Chemical Properties
density 1.58±0.1 g/cm3(Predicted)
pka8.82±0.10(Predicted)
Safety Information
MSDS Information
5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- Usage And Synthesis
UsesmHTT-IN-1 (Example 1) is a potent mutant huntingtin (mHTT) inhibitor. mHTT is toxic and a major cause of the inherited autosomal dominant neurodegenerative disorder, Huntington's disease (HD). mHTT-IN-1 conducts the reduction of mHTT with an EC50 value of 46 nM[1].
References[1] Brom, et al. Preparation of thiazolopyrimidinone derivatives and uses thereof. World Intellectual Property Organization, WO2022194801 A1. 2022-09-22.
5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)- Preparation Products And Raw materials
Tag:5H-Thiazolo[3,2-a]pyrimidin-5-one, 7-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-(1-piperazinyl)-(2839311-21-4) Related Product Information
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