5-Chloro-1-methyl-1H-indole-2-carboxylic acid manufacturers
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| | 5-Chloro-1-methyl-1H-indole-2-carboxylic acid Basic information |
| Product Name: | 5-Chloro-1-methyl-1H-indole-2-carboxylic acid | | Synonyms: | TIMTEC-BB SBB011233;AKOS JY2082728;ASINEX-REAG BAS 10142185;1H-Indole-2-carboxylic acid, 5-chloro-1-Methyl-;5-chloro-1-methylindole-2-carboxylic acid;5-chloro-1-methyl-2-indolecarboxylic acid;5,7-diethyl-2-(3-nitrophenyl)-1,3-diazaadamantan-8-one;5-Chloro-1-methyl-1H-indole-2-carboxylic acid | | CAS: | 59908-47-3 | | MF: | C10H8ClNO2 | | MW: | 209.63 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 5-Chloro-1-methyl-1H-indole-2-carboxylic acid Chemical Properties |
| Boiling point | 420.6±25.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.93±0.30(Predicted) | | Appearance | White to light yellow Solid |
| Hazard Codes | Xi,Xn | | Risk Statements | 22 | | HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 5-Chloro-1-methyl-1H-indole-2-carboxylic acid Usage And Synthesis |
| Synthesis | Step 2: Synthesis of 5-chloro-1-methyl-1H-indole-2-carboxylic acid (43.2)
To a THF solution (10 mL) of methyl 5-chloro-1-methyl-1H-indole-2-carboxylate (43.1, 224 mg) was added an aqueous solution (2 mL) of LiOH (36 mg, 1.5 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was dissolved in 1N aqueous hydrochloric acid solution (10 mL). The resulting suspension was allowed to stand for 10 minutes, then filtered through filter paper, collected as a solid and dried under vacuum to afford 163 mg (77.6% yield) of 5-chloro-1-methyl-1H-indole-2-carboxylic acid (43.2) as a beige powder. | | References | [1] Patent: KR101725451, 2017, B1. Location in patent: Paragraph 0294; 0301-0303
[2] Patent: WO2016/40449, 2016, A1. Location in patent: Paragraph 00508-00509
[3] Patent: WO2006/66879, 2006, A2. Location in patent: Page/Page column 53; 48
[4] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 21, p. 5664 - 5671 |
| | 5-Chloro-1-methyl-1H-indole-2-carboxylic acid Preparation Products And Raw materials |
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